By Francesco Collamati

This thesis specializes in a singular radio-guided surgical procedure procedure for entire tumor resections. It describes all facets of the intraoperative probe, in addition to trying out and simulation of the radical procedure. The presentation develops the procedure from the preliminary concept to sensible feasibility stories which have been the topic of a statement of the yankee Society of Nuclear medication. only a yr after finishing this paintings, the approach has now been proven for the 1st time on a meningioma sufferer, confirming all the predictions made during this thesis.
 

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Comparison of the Geant4 electromagnetic physics models against the NIST reference data. IEEE Trans. Nucl. Sci. 52, 910 (2005) 5. J. Birks, The Theory and Practice of Scintillation Counting (Pergamon, Oxford, 1964) 6. K. , Comparison of the Geant4 electromagnetic physics models against the NIST reference data. IEEE Trans. Nucl. Sci. 52, 910 (2005) 7. G. , The fluka code: description and benchmarking, in Proceedings of the Hadronic Shower Simulation Workshop 2006, Fermilab 6–8 Sept 2006, pp. 31–49 (2007) Chapter 4 Medical Applications In Chap.

On the other hand, a different estimation of the specific energy loss of the α particle, depending on the medium density, would result in a different evaluation of the k B factor from the same experimental data. 3 Photon Sensitivity One of the key-feature of the probe to be effective in the Radio Guided Surgery context is its sensitivity to the signal. As stated in Sect. 2, the idea of using β − tracers arises from the goal of having a highly specific signal to detect. To this aim, a low sensitivity to every form of pollution must be reached, for example from Bremsstrahlung photons, or photons produced in the decay of a non pure beta emitter isotope.

2 already reflect the optimal point in this balance. Regarding lateral shielding, on the other hand, the optimization is much less straightforward, and requires a tailored study. For this purpose, a setup similar to the one described in Sect. 1 was simulated. 5 mm) nested within a “background” zone (r = 2 cm, h = 1 cm), being the ratio between the 90 Y activities of the two zones 10:1. A number of different probe configurations were exposed to such a source, starting from the three prototypes presented in Sect.

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